H. Waterbeemd: search on Z-Library

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1

ADMET in silico modelling: towards prediction paradise?

van de Waterbeemd, Han, Gifford, Eric

Journal:

Nature Reviews Drug Discovery

Year:

2003

Language:

english

File:

PDF, 701 KB

english, 2003

2

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability Volume 40 || Application of the Biopharmaceutics Classification System Now and in the Future

van de Waterbeemd, Han, Testa, Bernard

Year:

2008

Language:

english

File:

PDF, 1.44 MB

english, 2008

3

Programs and Methods for Calculation of log P-values

Han van De Waterbeemd, Raimund Mannhold

Journal:

Molecular Informatics

Year:

1996

Language:

english

File:

PDF, 211 KB

english, 1996

4

Estimation of Blood-Brain Barrier Crossing of Drugs Using Molecular Size and Shape, and H-Bonding Descriptors

Chretien, Jacques R., Raevsky, Oleg A., van de Waterbeemd, Han, Camenisch, Gian, Folkers, Gerd

Journal:

Journal of Drug Targeting

Year:

1998

Language:

english

File:

PDF, 1.08 MB

english, 1998

5

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || High-Throughput Measurement of log D and pKa

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Year:

2003

Language:

english

File:

PDF, 372 KB

english, 2003

6

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

Fort, Kyle L., van de Waterbeemd, Michiel, Boll, Dmitriy, Reinhardt-Szyba, Maria, Belov, Mikhail E., Sasaki, Eita, Zschoche, Reinhard, Hilvert, Donald, Makarov, Alexander A., Heck, Albert J. R.

Journal:

The Analyst (Royal Society of Chemistry)

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

7

Pharmacokinetics and Metabolism in Drug Design (SMITH:PHARMACOKINETICS 3E O-BK) || Physicochemistry

Smith, Dennis A., Allerton, Charlotte, Kalgutkar, Amit S., van de Waterbeemd, Han, Walker, Don K.

Year:

2012

Language:

english

File:

PDF, 166 KB

english, 2012

8

Pharmacokinetic Optimization in Drug Research || Concepts in Prodrug Design to Overcome Pharmacokinetic Problems

Testa, Bernard, van de Waterbeemd, Han, Folkers, Gerd, Guy, Richard

Year:

2001

Language:

english

File:

PDF, 301 KB

english, 2001

9

[Methods and Principles in Medicinal Chemistry] Advanced Computer-Assisted Techniques in Drug Discovery || Frontmatter

van de Waterbeemd, Han

Year:

1994

Language:

english

File:

PDF, 610 KB

english, 1994

10

Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry

Snijder, Joost, van de Waterbeemd, Michiel, Damoc, Eugen, Denisov, Eduard, Grinfeld, Dmitry, Bennett, Antonette, Agbandje-McKenna, Mavis, Makarov, Alexander, Heck, Albert J. R.

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 1.72 MB

english, 2014

11

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || Cell Cultures in Drug Discovery: An Industrial Perspective

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Year:

2003

Language:

english

File:

PDF, 344 KB

english, 2003

12

Lipophilicity and Other Parameters Affecting Brain Penetration

Atkinson, F., Cole, S., Green, C., van de Waterbeemd, H.

Journal:

Current Medicinal Chemistry - Central Nervous System Agents

Year:

2002

Language:

english

File:

PDF, 131 KB

english, 2002

13

L-Dopa Methyl Ester—A Candidate for Chronic Systemic Delivery of L-Dopa in Parkinsonʼs Disease

Cooper, D. R., Marrel, C., Testa, B., van de Waterbeemd, H., Quinn, N., Jenner, P., Marsden, C. D.

Journal:

Clinical Neuropharmacology

Year:

1984

File:

PDF, 4.84 MB

1984

14

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || Application of the Biopharmaceutic Classification System Now and in the Future

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Year:

2003

Language:

english

File:

PDF, 742 KB

english, 2003

15

[Methods and Principles in Medicinal Chemistry] Advanced Computer-Assisted Techniques in Drug Discovery || Rational Use of Chemical and Sequence Databases

van de Waterbeemd, Han

Year:

1994

Language:

english

File:

PDF, 4.26 MB

english, 1994

16

[Methods and Principles in Medicinal Chemistry] Chemometric Methods in Molecular Design (van de Waterbeemd/Chemometric) ||

van de Waterbeemd, Han

Year:

1995

Language:

english

File:

PDF, 17.96 MB

english, 1995

17

Evaluation of a critical process parameter: Oxygen limitation during cultivation has a fully reversible effect on gene expression of Bordetella pertussis

Mathieu Streefland, Bas van de Waterbeemd, Joeri Kint, Leo A. van der Pol, E. Coen Beuvery, Johannes Tramper, Dirk E. Martens

Journal:

Biotechnology and Bioengineering

Year:

2009

Language:

english

File:

PDF, 310 KB

english, 2009

18

Gene-expression-based quality scores indicate optimal harvest point in Bordetella pertussis cultivation for vaccine production

Bas van de Waterbeemd, Mathieu Streefland, Jeroen Pennings, Leo van der Pol, Coen Beuvery, Johannes Tramper, Dirk Martens

Journal:

Biotechnology and Bioengineering

Year:

2009

Language:

english

File:

PDF, 434 KB

english, 2009

19

A practical approach for exploration and modeling of the design space of a bacterial vaccine cultivation process

M. Streefland, P.F.G. Van Herpen, B. Van de Waterbeemd, L.A. Van der Pol, E.C. Beuvery, J. Tramper, D.E. Martens, M. Toft

Journal:

Biotechnology and Bioengineering

Year:

2009

Language:

english

File:

PDF, 647 KB

english, 2009

20

Improving Compound Quality through in vitro and in silico Physicochemical Profiling

Han van de Waterbeemd

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 118 KB

english, 2009

21

ChemInform Abstract: Property-Based Design: Optimization of Drug Absorption and Pharmacokinetics

Han van de Waterbeemd, Dennis A. Smith, Kevin Beaumont, Don K. Walker

Journal:

Year:

2001

File:

PDF, 25 KB

2001

22

ChemInform Abstract: Substructure and Whole Molecule Approaches for Calculating Log P

Raimund Mannhold, Han Van de Waterbeemd

Journal:

Year:

2001

File:

PDF, 25 KB

2001

23

PCILO and CD. Conformational study of sulpiride, a dopamine antagonist

Han van de Waterbeemd, Bernard Testa

Journal:

Helvetica Chimica Acta

Year:

1981

Language:

english

File:

PDF, 285 KB

english, 1981

24

Basicity, Lipophilicity, and Lack of Receptor Interaction of N-Aminoalkylbenzamides and N-Aminoalkyl-o-anisamides as Model Compounds of Dopamine Antagonists

Lucien Anker, Bernard Testa, Han Van De Waterbeemd, Anne Bornand-Crausaz, Andreas Theodorou, Peter Jenner, C. David Marsden

Journal:

Helvetica Chimica Acta

Year:

1983

Language:

english

File:

PDF, 731 KB

english, 1983

25

NMR Conformational Study of Aminoalkylbenzamides, Aminoalkyl-o-anisamides, and Metoclopramide, a Dopamine Receptor Antagonist

Lucien Anker, Han Van De Waterbeemd, Bernard Testa, JÜRgen Lauterweiin

Journal:

Helvetica Chimica Acta

Year:

1984

Language:

english

File:

PDF, 605 KB

english, 1984

26

The Electronic Structure of Dopamine. An ab initio Electrostatic Potential Study of the Catechol Moiety

Han van de Waterbeemd, Pierre-Alain Carrupt, Bernard Testa

Journal:

Helvetica Chimica Acta

Year:

1985

Language:

english

File:

PDF, 518 KB

english, 1985

27

Quantitative Structure-Affinity Relationships of Dopamine D2 Receptor Antagonists: A Comparison between Orthopramides and 6-Methoxysalicylamides

Tomas de Paulis, Nabil El Tayar, Pierre-Alain Carrupt, Bernard Testa, Han van de Waterbeemd

Journal:

Helvetica Chimica Acta

Year:

1991

Language:

english

File:

PDF, 707 KB

english, 1991

28

Biosensor analysis of the interaction between drug compounds and liposomes of different properties; a two-dimensional characterization tool for estimation of membrane absorption

Åsa Frostell-Karlsson, Helena Widegren, Caroline E. Green, Markku D. Hämäläinen, Lena Westerlund, Robert Karlsson, Katherine Fenner, Han van de Waterbeemd

Journal:

Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 234 KB

english, 2005

29

Transport in quantitative structure-activity relationships VI: Relationship between transport rate constants and partition coefficients

Han Van De Waterbeemd, Paul Van Bakel, Adri Jansen

Journal:

Journal of Pharmaceutical Sciences

Year:

1981

Language:

english

File:

PDF, 221 KB

english, 1981

30

Predictivity of Simulated ADME AutoQSAR Models over Time

Sarah L. Rodgers, Andrew M. Davis, Nick P. Tomkinson, Han van de Waterbeemd

Journal:

Molecular Informatics

Year:

2011

Language:

english

File:

PDF, 953 KB

english, 2011

31

Kinetics of growth and structure of thin films of tin

J.v.d. Waterbeemd

Journal:

Physics Letters

Year:

1965

Language:

english

File:

PDF, 133 KB

english, 1965

32

Interaction of neuroleptic drugs with rat striatal D-1 and D-2 dopamine receptors: a quantitative structure—affinity relationship study

Nabil El Tayar, Gavin J Kilpatrick, Han Van De Waterbeemd, Bernard Testa, Peter Jenner, C.David Marsden

Journal:

European Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 1.02 MB

english, 1988

33

QSAR of nortropane-substituted benzamides: use of lipophilic (RP-HPLC) and electronic (1H NMR) parameters

Sonia Collin, Nabil El Tayar, Han van de Waterbeemd, Florence Moureau, Daniel P Vercauteren, François Durant, Michel Langlois, Bernard Testa

Journal:

European Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 677 KB

english, 1989

34

Three-dimensional and electronic analysis of Na+-dependent antidopaminergic agents: tropapride and zetidoline

S Collin, D P Vercauteren, G Evrard, F Durant, H van de Waterbeemd, P A Carrupt, B Testa

Journal:

Journal of Molecular Graphics

Year:

1986

Language:

english

File:

PDF, 150 KB

english, 1986

35

Similarities of pharmacophoric patterns revealed by the MEP of metoclopramide, molindone and piquindone, a subgroup of dopamine D-2 receptor antagonists

H van de Waterbeemd, P A Carrupt, B Testa

Journal:

Journal of Molecular Graphics

Year:

1986

Language:

english

File:

PDF, 382 KB

english, 1986

36

Isotope effects on lipophilicity and polarity

J.B. Falconnet, J.L. Brazier, B. Testa, P.A. Carrupt, H. Van De Waterbeemd

Journal:

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes

Year:

1988

Language:

english

File:

PDF, 74 KB

english, 1988

37

Lipophilicity measurements of protonated basic compounds by reversed-phase high-performance liquid chromatography : II. Procedure for the determination of a lipophilic index measured by reversed-phase high-performance liquid chromatography

Nabil El Tayar, Han Van de Waterbeemd, Bernard Testa

Journal:

Journal of Chromatography A

Year:

1985

Language:

english

File:

PDF, 585 KB

english, 1985

38

Lipophilicity measurements of protonated basic compounds by reversed-phase high-performance liquid chromatography : I. Relationship between capacity factors and the methanol concentration in methanol-water eluents

Nabil El Tayar, Han van de Waterbeemd, Bernard Testa

Journal:

Journal of Chromatography A

Year:

1985

Language:

english

File:

PDF, 653 KB

english, 1985

39

Structural effects in the lipophilicity of di- and polysubstituted benzenes as measured by reversed-phase high-performance liquid chromatography

Anna Tsantili-Kakoulidou, Nabil El Tayar, Han Van De Waterbeemd, Bernard Testa

Journal:

Journal of Chromatography A

Year:

1987

Language:

english

File:

PDF, 866 KB

english, 1987

40

Physicochemical models for gastrointestinal absorption

Han van de Waterbeemd

Journal:

Year:

2000

Language:

english

File:

PDF, 200 KB

english, 2000

41

Pharmacokinetics and metabolism in early drug discovery

Dennis A Smith, Han van de Waterbeemd

Journal:

Current Opinion in Chemical Biology

Year:

1999

Language:

english

File:

PDF, 663 KB

english, 1999

42

Estimation of Caco-2 Cell Permeability using Calculated Molecular Descriptors

Han van De Waterbeemd, Gian Camenisch, Gerd Folkers, Oleg A. Raevsky

Journal:

Molecular Informatics

Year:

1996

Language:

english

File:

PDF, 882 KB

english, 1996

43

Time-Series QSAR Analysis of Human Plasma Protein Binding Data

Sarah L. Rodgers, Andrew M. Davis, Han van de Waterbeemd

Journal:

Molecular Informatics

Year:

2007

Language:

english

File:

PDF, 174 KB

english, 2007

44

Structure-lipophilicity relationships of peptides and peptidomimetics

N. El Tayar, H. Karajiannis, H. Waterbeemd

Journal:

Year:

1995

Language:

english

File:

PDF, 1.01 MB

english, 1995

45

Lipophilicity of amino acids

H. Waterbeemd, H. Karajiannis, N. El Tayar

Journal:

Year:

1994

Language:

english

File:

PDF, 1.08 MB

english, 1994

46

Pattern recognition study of QSAR substituent descriptors

Han van de Waterbeemd, Nabil El Tayar, Pierre -Alain Carrupt, Bernard Testa

Journal:

Journal of Computer-Aided Molecular Design

Year:

1989

Language:

english

File:

PDF, 901 KB

english, 1989

47

Transport in QSAR IV

J. Th. M. Waterbeemd, C. C. A. A. Boekel, R. L. F. M. Sévaux, A. C. A. Jansen, K. W. Gerritsma

Journal:

International Journal of Clinical Pharmacy

Year:

1981

Language:

english

File:

PDF, 965 KB

english, 1981

48

Transport in QSAR V

J. Th. M. Waterbeemd, A. C. A. Jansen

Journal:

International Journal of Clinical Pharmacy

Year:

1981

Language:

english

File:

PDF, 585 KB

english, 1981

49

Transport in QSAR III

J. TH. M. van De Waterbeemd, A. C. A. Jansen, K. W. Gerritsma

Journal:

International Journal of Clinical Pharmacy

Year:

1980

Language:

english

File:

PDF, 551 KB

english, 1980

50

Prediction of oral bioavailability by adaptive fuzzy partitioning

Marco Pintore, Han van de Waterbeemd, Nadège Piclin, Jacques R. Chrétien

Journal:

European Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 196 KB

english, 2003